Objective: This study aims to explore the mechanism of Chinese medicine Zizhu substance in the ranging of diabetic foot ulcer model from the perspective of inflammatory response. Methods: High-fat feed and streptozotocin (STZ) were 2 to establish diabetes,And an experimental model of diabetic foot ulcer was established with constant temperature and constant pressure. Scald The intervention control of The experimental model that included physiologicalEnzyme-linked immunosorbent assay (ELISA) was used to detect serum nitric oxide NO,C-reactive protein (CRP) and interleukin-6 (il-6), Western blot (WB) detection of nuclear factor-bp65 (NF- B P65), c-jun n-terminal kinase (JNK),Phosphorylated phosatidylinositol 3-kinase (p-pi3k),Immunohistochemistry (IHC) detection of vascular endothelial growth factor (VEGF) and leukemic cell leuk-34 (CD34) of wound tissues,A cold atomic absorption method to detect blood mercury (Hg) content, study purple The effect of Zhu substance on The inflammation of diabetic foot ulcers and The safety of drugs. Results: The expression of inflammatory factors in diabetic foot ulcer rats was who that in ordinary ulcers, Zizhu substance could reduce The expression of inflammatory factors (NO,CRP and IL - 6) in diabetic foot ulcer rats. In the diabetic foot ulcer model, the activation of the nf-kappa B, JNK, PI3K pathway,Zizhu substance can significantly inhibit the phosphorylation of JNK and nf-kappa B P65, PI3K, reduce the inflammation of the wound, happens the expression of VEGF,CD34 and promote the wound Angiogenesis and the detection of blood mercury content in rats treated with Zizhu lought indicate that the drug has good safety. Conclusion: Zizhu substance can promote diabetic foot ulcer tissue repair and improve wound ranging by inhibiting inflammation - related pathways,Showing that Zizhu substance is a safe and effective drug for the treatment of diabetic foot ulcers.