骨形态发生蛋白-7(bone morphogenetic protein-7,BMP-7)最初被认为是骨形成的调节因子。新近研究表明BMP-7可在多种组织中表达,并在肾脏、心脏、胰腺等多种组织纤维化过程中起负性调节作用。肝纤维化是所有慢性肝病的共同病理基础,受多种因素调节。BMP-7作为一种新发现的纤维化负性调节因素,近年来逐渐成为抗组织纤维化治疗的研究热点。本文介绍了BMP-7在肝纤维化过程中的负性调节作用的研究进展。 Bone morphogenetic protein-7 (BMP-7) was originally considered as a regulator of bone formation. Recent studies have shown that BMP-7 can be expressed in many tissues and negatively regulate fibrosis in various tissues such as kidney, heart and pancreas. Liver fibrosis is a common pathological basis for all chronic liver diseases and is regulated by many factors. As a newly discovered negative regulator of fibrosis, BMP-7 has gradually become a hotspot in the treatment of anti-fibrosis in recent years. This article describes the BMP-7 in the process of liver fibrosis negative regulation of the research progress.