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目的 探讨卵巢幼年型颗粒细胞瘤的诊断、治疗和预后。方法 回顾性分析自 1983年至 2 0 0 2年间北京协和医院收治的 4例卵巢幼年型颗粒细胞瘤的临床资料。结果 卵巢幼年型颗粒细胞瘤的发生率极低 ,主要发生在青少年及儿童。临床表现为盆腔实性包块伴胸腹水。 4例患者雌二醇水平均在正常范围 ,手术病理分期为Ⅰ期。确诊主要依据病理检查。所有患者接受手术 +化学药物治疗 (化疗 )。其中 ,2例呈高核分裂相的患者病情很快恶化 ,分别于发病后 10和 14个月死亡 ;2例低核分裂相的患者现无瘤生存分别为 32和 2 5个月。结论 卵巢幼年型颗粒细胞瘤的诊断主要依据病理检查。核分裂相高者预后不良。治疗以手术为主 ,辅以化疗可能改善预后。
Objective To investigate the diagnosis, treatment and prognosis of ovarian juvenile granulosa cell tumor. Methods The clinical data of 4 cases of ovarian juvenile granulosa cell carcinoma admitted to Peking Union Medical College Hospital from 1983 to 2002 were retrospectively analyzed. Results The incidence of ovarian juvenile granulosa cell tumor was extremely low, mainly in adolescents and children. Clinical manifestations of pelvic solid mass with pleural effusion. 4 patients with estradiol levels were in the normal range, surgical pathology stage Ⅰ. The main diagnosis based on pathological examination. All patients underwent surgery + chemotherapy (chemotherapy). Among them, two cases of patients with high-mitotic phase deteriorated rapidly and died at 10 and 14 months after onset respectively. The two patients with low-mitotic phase had a tumor-free survival of 32 and 25 months respectively. Conclusion The diagnosis of ovarian juvenile granulosa cell tumor is mainly based on pathological examination. High schizophrenia with poor prognosis. Surgery-based treatment, supplemented with chemotherapy may improve the prognosis.