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[目的]探讨BRCA-1和IGF-1R在Cerb B-2高表达乳腺癌组织中的表达及临床意义。[方法 ]应用免疫组织化学SP法检测BRCA-1和IGF-1R在29例Cerb B-2高表达的乳腺癌组织、20例Cerb B-2低表达的乳腺癌组织和10例乳腺增生症组织中的表达情况。[结果]在Cerb B-2高表达的乳腺癌中,BRCA-1表达与组织学分级、腋窝淋巴结转移、术后复发转移密切相关(P<0.05),与患者年龄、肿瘤大小、雌激素及孕激素受体状况无关(P>0.05);IGF-1R表达与患者年龄、肿瘤大小、组织学分级、腋窝淋巴结转移、术后复发及雌激素与孕激素受体状况无关(P>0.05)。Kaplan-Meier生存分析结果表明BRCA-1和IGF-1R的表达与总生存期均无明显相关(P>0.05)。[结论]乳腺上皮中BRCA-1蛋白的表达减少与缺失和IGF-1R的表达增加与Cerb B-2高表达的乳腺癌的发生和发展密切关系,两者有望成为代替或协助Cerb B-2判断乳腺癌恶性程度、预后及指导治疗的生物学新指标。
[Objective] To investigate the expression and clinical significance of BRCA-1 and IGF-1R in Cerb B-2 overexpression breast cancer. [Methods] The expression of BRCA-1 and IGF-1R in 29 cases of Cerb B-2 overexpressing breast cancer tissue, 20 cases of Cerb B-2 low expression breast cancer tissue and 10 cases of hyperplasia of breast tissue were detected by immunohistochemical SP method. In the expression of the situation. [Results] The expression of BRCA-1 in breast cancer with high expression of Cerb B-2 was closely related to histological grading, axillary lymph node metastasis and postoperative recurrence and metastasis (P <0.05), but not with age, tumor size, estrogen and The expression of IGF-1R had no correlation with the age, tumor size, histological grade, axillary lymph node metastasis, postoperative recurrence and estrogen and progesterone receptor status (P> 0.05). Kaplan-Meier survival analysis showed that the expression of BRCA-1 and IGF-1R had no significant correlation with the overall survival (P> 0.05). [Conclusion] The decrease and deletion of BRCA-1 protein in mammary epithelium and the increased expression of IGF-1R are closely related to the occurrence and development of breast cancer with high expression of Cerb B-2. Both of them are expected to become the substitute or assistance for Cerb B-2 To determine the degree of malignancy of breast cancer, prognosis and guidance of biological treatment of new indicators.