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AIM To investigate serum urokinase-type plasminogen activator receptor(u PAR) and liver stiffness in biliary atresia(BA) and examine the correlation of circulating u PAR, liver stiffness, and clinical outcomes in postoperative BA children.METHODS Eighty-five post Kasai BA children and 24 control subjects were registered. Circulating u PAR was measured using enzyme-linked immunosorbent essay. Liver stiffness was analyzed using transient elastography.RESULTS BA children had significantly greater circulating u PAR andliver stiffness scores than control subjects(P < 0.001). Circulating u PAR and liver stiffness were substantially higher in jaundiced BA children than non-jaundiced BA children(P < 0.001). In addition, circulating u PAR was positively associated with serum aspartate aminotransferase(r = 0.507, P < 0.001), alanine aminotransferase(r = 0.364, P < 0.001), total bilirubin(r = 0.559, P < 0.001), alkaline phosphatase(r = 0.325, P < 0.001), and liver stiffness scores(r = 0.508, P < 0.001).CONCLUSION Circulating u PAR and liver stiffness values were greater in BA children than healthy controls. The increased circulating u PAR was associated with liver dysfunction in BA. As a consequence, serum u PAR and liver stiffness may be used as noninvasive biomarkers indicating the progression of liver fibrosis in post Kasai BA.
AIM To investigate serum urokinase-type plasminogen activator receptor (u PAR) and liver stiffness in biliary atresia (BA) and examine the correlation of circulating u PAR, liver stiffness, and clinical outcomes in postoperative BA children. METHODS Eighty-five post Kasai BA Circulating u PAR was measured using enzyme-linked immunosorbent essay. Outcomes BA children had significantly greater u u than and control stiffness subjects than control subjects (P <0.001). Circulating u PAR was measured using enzyme-linked immunosorbent essay. u PAR and liver stiffness were substantially higher in jaundiced BA children than non-jaundiced BA children (P <0.001). In addition, circulating u PAR was positively associated with serum aspartate aminotransferase (r = 0.507, P <0.001), alanine aminotransferase (r = 0.364, P <0.001), total bilirubin (r = 0.559, P <0.001), alkaline phosphatase 0.001) .CONCLUSION Circulating u PAR and liver stiffness values were greater in BA children than healthy controls. The increased circulating u PAR was associated with liver dysfunction in BA. As a consequence, serum u PAR and liver stiffness may be used as noninvasive biomarkers indicating the progression of liver fibrosis in post Kasai BA.