论文部分内容阅读
目的:探究阿魏酸钠联合双黄连注射液对病毒性心肌炎患者临床疗效及血清基质金属蛋白酶、锌铜水平的影响。方法:选择在我院确诊为病毒性心肌炎的患者39例,随机分成实验组以及对照组。对照组18例给予阿魏酸钠治疗;实验组21例予阿魏酸钠联合双黄连注射液治疗。治疗14天后,评价和比较两组患者的临床疗效、心肌酶谱水平、血清基质金属蛋白酶水平及血清锌铜比值。结果:实验组总有效率为95.2%,显著高于对照组(72.2%),差异具统计学意义(P<0.05)。与对照组比,实验组治疗后的血清、乳酸脱氢酶(LDH)水平、肌酸磷酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、基质金属蛋白酶水平较低,血清铜锌比值较小,而左室射血分数(LVEF)水平较高,差异均具有统计学意义(P<0.05)。结论:阿魏酸钠联合双黄连注射液治疗病毒性心肌炎患者能够有效提高其临床疗效,可能与其显著降低血清基质金属蛋白酶及铜锌水平有关。
Objective: To investigate the clinical efficacy of sodium ferulate combined with Shuanghuanglian injection in patients with viral myocarditis and serum matrix metalloproteinase, zinc and copper levels. Methods: Thirty-nine patients diagnosed as viral myocarditis in our hospital were randomly divided into experimental group and control group. Control group, 18 cases were given sodium ferulate; experimental group, 21 cases were treated with sodium ferulate and Shuanghuanglian injection. After 14 days of treatment, the clinical efficacy, myocardial zymogram, serum matrix metalloproteinase level and serum zinc-copper ratio were evaluated and compared between the two groups. Results: The total effective rate was 95.2% in the experimental group, which was significantly higher than that in the control group (72.2%), the difference was statistically significant (P <0.05). Compared with the control group, the levels of serum LDH, CK-MB, AST and MMP in the experimental group were significantly higher than those in the control group Low, serum copper-zinc ratio was small, and left ventricular ejection fraction (LVEF) levels were higher, the difference was statistically significant (P <0.05). Conclusion: Sodium ferulate combined with Shuanghuanglian injection in patients with viral myocarditis can effectively improve its clinical efficacy, which may be related to its significant reduction of serum matrix metalloproteinase and copper and zinc levels.