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纳米粒子(20~400 nm)颗粒小,可通过血管的渗透增强和滞留效果而积累在肿瘤细胞中,避免被肾脏所清除,从而使其在血管中有更长的血液循环时间;纳米粒子比表面积大,可以携带大量的化疗药物用于药物的传递;纳米粒子表面经过改造后可以结合不同的靶向基团,并利用共价键结合到细胞表面受体,从而可将药物运输到特定的部位。近年来,越来越多的科研工作者致力于研究纳米颗粒与一些生物分子之间的关系,以此来开发更有效和特异性的抗癌药物。引用了近10年的参考文献,主要介绍了纳米粒子在肿瘤成像及治疗中的应用。
Nanoparticles (20-400 nm) are small particles that accumulate in tumor cells through the enhancement and retention of blood vessels and are prevented by the kidneys, allowing them to have longer blood circulation times in the blood vessels. Nanoparticles Large surface area, can carry a large number of chemotherapy drugs for drug delivery; nano-particle surface can be modified to combine different targeting groups, and the use of covalent bonds to the cell surface receptors, which can be drug delivery to a specific Site. In recent years, more and more researchers devoted themselves to studying the relationship between nanoparticles and some biological molecules in order to develop more effective and specific anticancer drugs. Cited nearly 10 years of reference, mainly introduced the application of nanoparticles in tumor imaging and treatment.