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目的：探讨孤立性纤维性肿瘤（SFT）的病理形态及免疫组织化学特征。方法对5例 SFT 进行形态学和免疫组织化学染色观察，结合文献对其病理形态特点进行分析。结果本组病例发生于纵隔及眼眶。肿瘤直径2-10cm，边界清，包膜完整。镜下以梭形细胞为主，呈束状、编织状排列，由交替分布的富于细胞区和细胞稀疏区组成，有大量粗大胶原纤维。有血管外皮瘤样表现及及血管壁增厚透明变，粘液变性明显等特征。免疫组化染色显示肿瘤细胞 CD34、CD99、Bcl-2、Vim 均阳性。结论 SFT是一种少见肿瘤，可发生胸膜及全身各部位。有较独特的病理形态特征。生物学行为不肯定，需定期随访。“,”Objective To investigate the solitary fibrous tumor (SFT) pathological and immunohistochemical features. Method The morphology and immunohistochemical staining of 5 cases of SFT were observed, and the pathological characteristics were analyzed with the literature. Result This group of cases occurred in the mediastinal and orbital. Tumor diameter 2-10cm, clear boundary, complete envelope. Mirror to spindle shaped cel s, arranged in bundles, woven like arrangement, consisting of alternating distribution of ful cel area, and cel sparse zone composition, there are a large number of thick col agen fibers. There are vascular skin tumor like manifestations and thickening of the vascular wal thickening and transparent, mucus degeneration and other characteristics. Immunohistochemical staining showed that the tumor cel s were positive for CD34, CD99, Bcl-2 and Vim. Conclusion SFT is a rare tumor, which can occur in various parts of the pleural and the whole body. Have more unique pathological characteristics. Biological behavior is not sure, need regular fol ow-up.