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目的:观察抗血栓药材醇提物的活血化瘀作用。方法:采用小鼠脑偏瘫、血小板聚集、毛细玻璃管法、高脂血症模型、急性血瘀证模型等试验方法,测定药物对小鼠脑血栓的保护率,血小板聚集的电阻率、凝血时间、血脂水平及对血液粘度的影响。结果:苦丁茶、山绿茶、绞股蓝、田七叶等对小鼠脑血栓模型有一定保护作用;苦丁茶、绞股蓝、田七叶等对血小板聚集有一定抑制作用;两面针、肉桂皮、绞股蓝、田七叶等具有抗凝作用;两面针、山绿茶、肉桂皮、山楂叶、绞股蓝、田七叶等具有降低血脂作用;两面针、山绿茶、山楂叶、绞股蓝等可改善急性“血瘀证”大鼠血液流变学指标。结论:本试验初筛结果为开发利用抗血栓药材提供了科学依据。
Objective: To observe the effect of promoting blood circulation and removing blood stasis of alcohol extracts from antithrombotic herbs. METHODS: The protective rates of drugs against cerebral thrombosis in mice, the electrical resistivity of platelet aggregation, and the clotting time were determined using mouse hemiplegia, platelet aggregation, capillary glass tube method, hyperlipidemia model, and model of acute blood stasis syndrome. , blood lipid levels and the impact on blood viscosity. Results: Kuding tea, green tea, Gynostemma pentaphyllum and Tiadenia chinensis had a certain protective effect on mouse cerebral thrombosis model; Kudingcha, Gynostemma pentaphyllum and Tianqiye had a certain inhibitory effect on platelet aggregation; Zanthoxylum, cinnamon bark, Gynostemma pentaphylla and Tiadenia officinalis etc. have anticoagulant effect; M. acuminatum, green tea, cinnamon bark, hawthorn leaves, gynostemma pentaphyllum, and tianqiye have the function of lowering blood lipids; mianqianzhen, moutain green tea, hawthorn leaves and gynostemma can improve acute blood. “Stagnation syndrome” rat hemorheology index. Conclusion: The preliminary screening results provided scientific basis for the development and utilization of antithrombotic materials.