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目的：研究清肝解毒丸对四氯化碳（ＣＣｌ４）肝损伤的保护作用和对人乙肝病毒（ＨＢＶ）抗原的抑制作用。方法：观察清肝解毒丸对动物ＣＣｌ４急性肝损伤和肝纤维化的效应及对ＨＢｅＡｇ和ＨＢｓＡｇ的体外抑制作用。结果：清肝解毒丸对ＣＣｌ４所致的急性肝损伤有显著的保护作用，并能减轻ＣＣｌ４引起的肝纤维化，以及在体外对ＨＢｅＡｇ和ＨＢｓＡｇ具有明显的抑制作用。结论：清肝解毒丸有显著的护肝作用和抗ＨＢＶ作用。
Objective: To study the protective effect of Qinggan Jiedu Pill on carbon tetrachloride (CCl4) liver injury and its inhibitory effect on human hepatitis B virus (HBV) antigen. Methods: To observe the effect of Qinggan Jiedu Pills on acute liver injury and hepatic fibrosis of animals with CCl4 and the inhibitory effect on HBeAg and HBsAg in vitro. RESULTS: Qinggan Jiedu Pill had a significant protective effect on acute hepatic injury caused by CCl4, and it also alleviated the liver fibrosis induced by CCl4, and had obvious inhibitory effect on HBeAg and HBsAg in vitro. Conclusion: Qinggan Jiedu Pills have significant hepatoprotective effect and anti-HBV effect.