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目的探讨纳他霉素滴眼剂对正常兔眼的刺激性。方法将20只新西兰白兔随机均分为那特真组、生理盐水组、纳他霉素滴眼剂组、赋形剂组。每组10只兔眼,每天用药8～10次,每次1滴,连续应用至第21天,停药后观察2 d。采用双盲法用裂隙灯观察兔眼刺激情况并评分。结果各实验组药物对正常兔眼均无刺激性,与生理盐水组比较,均无显著差异。结论纳他霉素滴眼剂对兔眼无刺激性,有着良好的发展前景。
Objective To investigate the irritability of natamycin eye drops to normal rabbit eyes. Methods Twenty New Zealand white rabbits were randomly divided into three groups: natriuretic group, normal saline group, natamycin eye drops group and vehicle group. Each group of 10 rabbit eyes, medication 8 to 10 times a day, each drop of 1, continuous application until the 21st day, after stopping the observation 2 d. Double-blind method using slit lamp to observe the rabbit eye irritation and score. Results The experimental group had no irritation to the normal rabbit eyes, no significant difference compared with the saline group. Conclusion natamycin eye drops no irritation to the rabbit eye, has a good prospect.