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目的探讨血液中分离的肺炎克雷伯菌耐碳青霉烯类抗菌药物的危险因素,为临床治疗提供理论依据。方法回顾性收集2009年6月至2012年12月期间血液中分离出肺炎克雷伯菌的住院患者的临床资料,采用病例对照研究,单因素分析和多因素Logistic回归分析血液感染肺炎克雷伯菌耐碳青霉烯类抗菌药物的危险因素。结果泌尿道插管、血型(A型)、使用氨基糖苷类及抗真菌类抗菌药物是血液感染肺炎克雷伯菌耐碳青霉烯类抗菌药物的独立危险因素。结论临床治疗过程中,需要特别注意的环节是:泌尿道插管;氨基糖苷类和抗真菌类抗菌药物的合理使用。
Objective To investigate the risk factors of Klebsiella pneumoniae resistant to carbapenem antibiotics isolated from blood and provide a theoretical basis for clinical treatment. Methods The clinical data of hospitalized patients with Klebsiella pneumonia isolated from June 2009 to December 2012 were collected retrospectively. Case-control study, univariate analysis and multivariate logistic regression analysis were used to analyze the blood infection of Klebsiella pneumoniae Risk factors for carbapenem - resistant antimicrobials. Results Urinary catheterization, blood type (A type), the use of aminoglycosides and antifungal antibiotics were independent risk factors for blood-borne anti-carbapenem-resistant antimicrobials of Klebsiella pneumoniae. Conclusion During the course of clinical treatment, special attention should be paid to the urinary tract intubation; the rational use of aminoglycosides and antifungal antibiotics.