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目的:获得使用舒血宁注射液后发生过敏反应患者相关影响因素,指导其临床安全用药。方法:基于全国20家三级甲等综合医院信息系统(HIS)数据库,采用处方序列分析(PSA),将使用舒血宁注射液当天即停止使用,且24h内又使用了地塞米松注射液的患者判断为疑似过敏反应患者98例,与采用巢式病例对照设计(NCCS)筛选的可能未发生过敏反应人群392例进行对比,探讨入院病情、过敏史、单次用药剂量、疾病、联合用药与疑似过敏反应发生的相关性。结果:通过分析发现,使用舒血宁注射液联合使用甲钴胺注射液(OR=7.246,P=0.0001)、参附注射液(OR=5.522,P<0.0001)、氯化钾注射液(OR=5.502,P<0.0001)、注射用头孢替安(OR=3.476,P=0.0022)、肝素注射液(OR=3.024,P=0.0012)、注射用泮托拉唑钠(OR=2.267,P=0.0238)均为疑似过敏反应发生的危险因素。结论:使用舒血宁注射液发生疑似过敏反应的患者危险因素可能与分别联合使用甲钴胺注射液、参附注射液、氯化钾注射液、注射用头孢替安、肝素注射液、注射用泮托拉唑钠等6种药物有关,未发现患者过敏史、入院病情、单次用药剂量、疾病与疑似过敏反应发生有明确关系。
OBJECTIVE: To obtain the influencing factors of patients with allergic reactions after using Shuxuening Injection and to guide their clinical safety medication. Methods: Based on the HIS database of 20 Class III A-level General Hospital in China, the prescription sequence analysis (PSA) was used to stop the use of Shuxuening injection on the same day and dexamethasone injection Of 98 patients with suspected allergic reaction were compared with 392 patients who may not have anaphylactic reaction using nested case-control design (NCCS) screening to investigate the incidence of illness, history of allergy, single dose, disease, combination therapy Correlation with suspected allergic reaction. Results: By using Shuxuening injection combined with methylcobalamin injection (OR = 7.246, P = 0.0001), Shenfu injection (OR = 5.522, P <0.0001), potassium chloride injection = 0.502, P <0.0001), cefotiam for injection (OR = 3.476, P = 0.0022), heparin injection (OR = 3.024, P = 0.0012) and pantoprazole sodium for injection (OR = 2.267, P = 0.0238) are suspected risk factors for allergic reactions. Conclusion: The risk factors of patients with suspected allergic reactions induced by Shuxuening Injection may be related to the combination of mecobalamin, Shenfu Injection, potassium chloride injection, cefotiam for injection, heparin injection, injection Pantoprazole sodium and other 6 kinds of drugs, found no history of allergies, admission conditions, single dose, disease and suspected allergic reactions have a clear relationship.