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5. DNA damage in nucleosomes

DNA damage in nucleosomes

来源 :中国科学:化学英文版 | 被引量 : 0次 | 上传用户：acdef2

【摘 要】

：

Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show differe

【作 者】

：

Mengtian Ren Jing Bai Zhen Xi 

【机 构】

：

StateKeyLaboratoryofElemento-OrganicChemistryandDepartmentofChemicalBiology

【出 处】

：

中国科学:化学英文版

【发表日期】

：

2019年5期

【关键词】

：

DNA damage DNA ALKYLATION DNA-protein CROSS-LINK NUCLEOSOME radical reactive int 

【基金项目】

：

supported by the National Natural Science Foundation of China(21572109,21877064,21740002),the National Key R&D Program of China(2017YFD0200501).

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Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show different properties toward exogenous and endogenous DNA-damaging agents. This review summarizes nucle

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