A 10-yr regional climate simulation was performed using the fifth-generation PSU/NCAR Mesoscale Model Version 3 (MM5V3) driven by large-scale NCEP/NCAR reanalyses. Simulations of winter and summer mean regional climate features were examined against observations. The results showed that the model could well simulate the 10-yr winter and summer mean circulation, temperature, and moisture transport at middle and low levels. The simulated winter and summer mean sea level pressure agreed with the NCAR/NCEP reanalysis data. The model could well simulate the distribution and intensity of winter mean precipitation rates as well as the distribution of summer mean precipitation rates, but it overestimated the summer mean precipitation over North China. The models ability to simulate the regional climate change in winter was superior to that in summer. In addition, the model could simulate the inter-annual variation of seasonal precipitation and surface air temperature. Geopotential heights and temperature at middle and high levels between simulations and observations exhibited high anomaly correlation coefficients. The model also showed large variability to simulate the regional climate change associated with the El Nino events. The MM5V3 well simulated the anomalies of summer mean precipitation in 1992 and 1995, while it demonstrated much less ability to simulate that in 1998. Generally speaking, the MM5V3 is capable of simulating the regional climate change, and could be used for long-term regional climate simulation.