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[目的]探讨中药复方益胃散对幽门螺杆菌(Hp)感染小鼠的影响。[方法]C57BL/6小鼠68只,随机分为正常对照(正常)组,模型组,益胃散小、中、大剂量(小、中、大剂量)组及三联(西药)组。除正常组外,其余5组制备Hp感染小鼠模型。各组分别予相应的药物治疗,模型组给予相应体积的0.85%氯化钠。停药后24 h及2周分别进行快速尿素酶试验、细菌培养和组织形态学观察。[结果]小、中剂量组与西药组对Hp感染的治疗效果相似,差异无统计学意义,大剂量组则效果较差;形态学改变,中、小剂量组治疗作用优于西药组(P<0.05)。[结论]益胃散对Hp有一定的抑制、清除作用,对受损胃黏膜有较好的保护、促修复作用。
[Objective] To investigate the effect of Yiwei Powder, a traditional Chinese compound herbal medicine, on Helicobacter pylori (Hp) infection in mice. [Methods] 68 C57BL/6 mice were randomly divided into normal control (normal) group, model group, Yiweisan small, medium, high dose (small, medium, high dose) group and triple (Western medicine) group. In addition to the normal group, the remaining 5 groups were prepared Hp infection mouse model. Each group was given corresponding drug treatment, and the model group was given a corresponding volume of 0.85% sodium chloride. Rapid urease test, bacterial culture and histomorphological observations were performed 24 h and 2 weeks after drug withdrawal. [Results] The therapeutic effects of small and medium dose group and western medicine group on Hp infection were similar, the difference was not statistically significant, but the effect was poor in large dose group; the morphological changes were significant, and the therapeutic effect of middle and small dose group was better than that of western medicine group (P <0.05). [Conclusion] Yiwei Powder has a certain inhibition and scavenging effect on Hp, and has a good protection and repair effect on damaged gastric mucosa.