论文部分内容阅读
本文对11例末次服用丙硫苯咪唑后12小时施行外科手术的棘球蚴患者,测定了患者的血清、肝、胆汁、肺和棘球蚴包囊壁和囊液中的丙硫咪唑及其主要代谢物——丙硫咪唑亚砜的浓度。每天口服丙硫咪唑10～14mg/kg后,发现丙硫咪唑含量在每克肝脏(湿重)中为1844±904ng,每克肺(湿重)中为749±34ng,在棘球蚴包囊液中为921±314ng/ml。此药也通过胆汁排泄。每天口服上述剂量,于治疗后2～4天,该药的血浓度是稳定的(600～1,000ng/ml)。此外,为了评价丙硫咪唑的疗效,作者用该药又治疗10例棘球蚴病人。其中3例患
In this paper, eleven patients with echinococcosis who underwent surgery 12 hours after the last administration of albendazole were tested for serum, liver, bile, and pulmonary cyst and hydatid cyst with albendazole and its major metabolites - The concentration of albendazole sulfoxide. After oral administration of albendazole 10 to 14 mg / kg daily, albendazole was found to be 1844 ± 904 ng per gram of liver (wet weight) and 749 ± 34 ng per gram of lung (wet weight) The solution was 921 ± 314 ng / ml. The drug is also excreted through the bile. Oral daily oral dose, 2 to 4 days after treatment, the drug’s blood concentration is stable (600 ~ 1,000ng / ml). In addition, in order to evaluate the efficacy of albendazole, the authors used the drug to treat 10 cases of hydatid disease. Three of them were affected