妊娠期逐渐增加的雌激素不断地刺激垂体,致泌乳素的分泌上升,由于雌激素又有阻止泌乳素在乳腺内合成乳汁的作用,故妊娠期无乳汁分泌,产后雌激素下降,而泌乳素仍在高水平,随即发生升乳。此后高泌乳素水平由频繁而有规律地吮吸乳头的刺激作用来维持,这作用甚至可维持数年之久。相反,早产儿或新生儿有病致吮吸无力可引起泌乳素下降,精神因素也能干扰泌乳素的分泌。为了纠正升乳延迟并改善乳汁分泌,曾试用促甲状腺激素释放素与灭吐灵(metoclopramide),获得一定疗效。本文拟对止呕灵(sulpiride)在这方面的作用进行探讨,后者在下丘脑受体水平发 Gestational estrogen gradually increased stimulation of the pituitary gland, causing increased secretion of prolactin, estrogen and lactase have to prevent lactation in the mammary gland synthesis, so no pregnancy secretion of milk, postpartum estrogen decreased, and prolactin Still high level, then raise milk. Since then, high prolactin levels by the frequent and regular sucking nipples to maintain the role of stimulation, the effect can be maintained for several years. In contrast, premature babies or newborns sick to suck weakness can cause prolactin decline, mental factors can interfere with prolactin secretion. In order to correct delay in raising milk and improve milk secretion, thyrotrophin releasing hormone and metoclopramide have been tested, and some curative effect has been obtained. This article intends to discuss the role of the sulpiride in this area, which develops at the hypothalamic receptor level