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目的 探讨 CA2 42 ,CA5 0和层粘连蛋白 (L N )水平与大肠癌转移及病理分期的关系 .方法 采用放射免疫分析法 .结果 38例大肠癌患者术前 CA2 42 ,CA5 0和 L N血清含量明显高于术后 (P<0 .0 1,P<0 .0 5和 P<0 .0 5 ) ;2 7例有淋巴结转移者 CA2 42 ,CA5 0及 L N血清含量明显高于 11例无淋巴结转移者 (P<0 .0 1,P<0 .0 5和 P<0 .0 5 ) ;Dukes病理分期中 ,CA2 42血清含量 期组 (16例 )高于 期组 (11例 ) , 期组高于 + 期组 (11例 ) ,差异均非常显著 (P<0 .0 1) ;CA5 0血清含量 , 期组和 期组均明显高于 + 期组 (P<0 .0 1) ;L N血清含量 , 期组高于 + 期组 (P<0 .0 5 ) .结论 CA2 42 ,CA5 0含量与大肠癌的病理分期和转移密切相关 ,对病情监测及预后有一定的临床价值
Objective To investigate the relationship between the levels of CA2 42, CA5 0 and laminin (LN) and the metastasis and pathological stage of colorectal cancer.Methods Radioimmunoassay was used.Results The serum levels of CA2 42, CA5 0 and LN before surgery in 38 patients with colorectal cancer were significantly (P0.01, P0.05 and P0.05). Serum levels of CA2 42, CA5 0 and LN in 27 patients with lymph node metastasis were significantly higher than those in 11 patients without lymph node metastasis (P <0.01, P <0.05 and P <0.05). In the Dukes pathological stage, the serum CA2 42 group (16 cases) was higher than the control group (11 cases) (P <0.01). The serum levels of CA5 0 in the period group and the period group were significantly higher than those in the + period group (P <0.01). LN serum was higher in the period group than in the period group (P0.05) .Conclusion The levels of CA2 42, CA5 0 are closely related to the pathological stage and metastasis of colorectal cancer, and have certain clinical value in disease monitoring and prognosis