作为违禁兽药的一类,广谱抗生素硝基呋喃类药物主要包括呋喃唑酮、呋喃它酮、呋喃西林和呋喃妥因四类,常用于治疗禽畜各类疾病,也在畜牧、水产等行业中被用于助长。该类药物半衰期较短,在生物体内迅速代谢产生相应代谢产物AOZ、AMOZ、SEM和AHD,原药及其代谢物具有致肿瘤、致癌、致畸胎、致生殖系统疾病等致病作用[1-3]。有研究表明,硝基呋喃类代谢物可以与蛋白质紧密结合,残留时间最长能达数月之久。但是摄入人体后,硝基呋 As a class of unlawful veterinary drugs, broad-spectrum antibiotics, nitrofuran drugs include furazolidone, furanketone, nitrofurazone and nitrofurantoin four categories, commonly used in the treatment of various diseases of livestock, but also in livestock husbandry, aquaculture and other industries are used to promote . The short half-life of these drugs, rapid metabolism in the body produce the corresponding metabolites AOZ, AMOZ, SEM and AHD, the original drug and its metabolites have caused tumor, carcinogenesis, teratogenic, reproductive system diseases and other pathogenic effects [1 -3]. Studies have shown that nitrofurans metabolites can be closely integrated with the protein, the longest retention time of up to several months. But after ingesting the body, nitrofurazone