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目的 :探讨血清多胺水平在肺癌诊断中的应用价值。方法 :建立肺癌大鼠模型 ,运用RP HPLC方法测定大鼠血清多胺水平 ,采用SPSS软件包进行统计学处理。结果 :实验组出现肿瘤的 16只大鼠血清精胺水平((5 .70± 1.77) μmol/L) 显著高于正常对照组大鼠血清精胺水平 ((4.83± 1.2 6 ) μmol/L) (P <0 .0 5 )。实验组未出现肿瘤的大鼠 (14只 )精胺水平 ((4.6 1± 1.83) μmol/L)与正常对照组精胺水平相比差异无显著性 (P >0 .0 5 ) ,实验组出现肿瘤的大鼠 (16只 )血清精胺水平显著高于实验组未出现肿瘤的大鼠 (14只 )血清精胺水平 (P <0 .0 5 )。实验组出现肿瘤的大鼠 (16只 )血清精脒水平 ((8.33± 2 .6 4) μmol/L)显著高于正常对照组大鼠血清精脒水平 ((5 .5 3± 2 .30 ) μmol/L) (P <0 .0 5 ) ,实验组未出现肿瘤的大鼠 (14只 )精脒水平 ((5 .39± 2 .30 ) μmol/L)与正常对照组大鼠血清精脒水平相比差异无显著性 (P >0 .0 5 ) ,而实验组出现肿瘤的大鼠 (16只 )精脒水平显著高于实验组未出现肿瘤的大鼠血清精脒水平 (P <0 .0 5 )。精胺和精脒 2项综合指标阳性率为 6 8.8%。结论 :血清多胺水平是肺癌诊断的一个有用指标。
Objective: To investigate the value of serum polyamines in the diagnosis of lung cancer. Methods: Lung cancer model was established in rats. The serum polyamines levels were determined by RP-HPLC. SPSS software package was used for statistical analysis. Results: Serum spermine levels (5.70 ± 1.77) μmol / L in 16 rats in the experimental group were significantly higher than those in the normal control group (4.83 ± 1.2 6 μmol / L) (P <0. 05). There was no significant difference in spermine level between the experimental group (14 rats) and spermine (4.6 ± 1.83) μmol / L) Serum spermine levels were significantly higher in tumor-bearing rats (16 rats) than in rats in the experimental group (14 rats) (P <0.05). The level of serum spermine (8.33 ± 2.64 μmol / L) in the experimental group (16 rats) was significantly higher than that of the normal control group ((5.53 ± 2.30 ) (μmol / L) (P <0.05). The levels of spermidine in the experimental group (5.39 ± 2.30μmol / L) and the normal control group There was no significant difference in spermidine level between the two groups (P> 0.05), but the level of spermine in rats in the experimental group (16 rats) was significantly higher than that in the experimental group <0 .0 5). The positive rate of spermine and spermidine in 2 items was 6 8.8%. Conclusion: The level of serum polyamines is a useful indicator for the diagnosis of lung cancer.