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目的探讨缺血性脑损害与血浆内皮素（ＥＴ）变化之间的关系，以及地塞米松（Ｄｍ）治疗效应的影响。方法采用线栓法制作一侧大脑中动脉栓塞（ＭＣＡ－Ｏ）大鼠模型；脑缺血再灌流组（ＩＲ）、地塞米松治疗组（ＩＲ＋Ｄｍ）于造型成功后１、６、２４、４８、９６ｈ采血２ｍｌ，取血浆；采用放免法测定ＥＴ。结果（１）ＩＲ、生理盐水对照组（ＩＲ＋ＮＳ）血浆ＥＴ含量显著增高（Ｐ＜０．０１，Ｐ＜０．００１）；（２）ＩＲ＋Ｄｍ组血浆ＥＴ含量较ＩＲ＋ＮＳ组显著降低（Ｐ＜０．０５，Ｐ＜０．０１）；同时脑缺血性病理损害明显减轻。结论（１）鼠血浆ＥＴ含量变化与脑缺血性损害病生机制密切相关；（２）地塞米松的应用对缺血脑组织有保护作用
Objective To investigate the relationship between ischemic brain damage and plasma endothelin (ET) and the effect of dexamethasone (Dm) treatment. Methods The rat model of middle cerebral artery occlusion (MCA-O) was established by thread occlusion. The cerebral ischemia-reperfusion group (IR) and dexamethasone treatment group (IR + Dm) , 96h blood 2ml, take plasma; measured by radioimmunoassay ET. Results (1) The content of plasma ET in IR and NS group was significantly higher than that in IR + NS group (P <0.01, P <0.001). 05, P <0.01). At the same time, cerebral ischemic pathological damage was significantly reduced. Conclusions (1) The change of plasma ET content in rats is closely related to the pathogenesis of cerebral ischemic damage. (2) The application of dexamethasone has a protective effect on ischemic brain tissue