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目的:探讨不同剂量阿托伐他汀对脑梗死患者临床疗效和血清CRP水平的影响。方法:选取2014年3月—2016年3月间收治的脑梗死患者96例,将其随机分为观察组48例和对照组48例;对照组患者给予阿伐他汀10 mg/d治疗,观察组患者给予阿伐他汀40 mg/d治疗,比较两组患者治疗前后血脂水平及血清CRP测定值。结果:两组患者治疗前TC、TG、LDL-C及HDL-C无明显改善(P>0.05),治疗后观察组患者TC、TG、LDL-C测得值低于对照组(P<0.05),HDL-C水平高于对照组(P<0.05);两组患者治疗前血清CRP水平无明显改善(P>0.05),治疗后观察组患者血清CRP水平显著低于对照组(P<0.05)。结论:相比于10 mg/d阿托伐他汀,40 mg/d阿托伐他汀用于治疗脑梗死患者更有助于调节血脂和降低血清CRP水平。
Objective: To investigate the effects of different doses of atorvastatin on clinical efficacy and serum CRP levels in patients with cerebral infarction. Methods: A total of 96 patients with cerebral infarction who were admitted to our hospital from March 2014 to March 2016 were randomly divided into observation group (48 cases) and control group (48 cases). Patients in the control group were treated with atorvastatin (10 mg / d) The patients were given atorvastatin 40 mg / d, and the blood lipid and serum CRP were compared between the two groups before and after treatment. Results: The levels of TC, TG, LDL-C and HDL-C in the two groups were not significantly improved before treatment (P> 0.05). After treatment, TC, TG and LDL-C in the observation group were lower than those in the control group (P <0.05). The levels of serum CRP in the two groups were not significantly improved before treatment (P> 0.05), and the levels of CRP in the observation group were significantly lower than those in the control group after treatment ). CONCLUSIONS: Atorvastatin 40 mg / day compared with atorvastatin at 10 mg / day is more useful in the treatment of patients with cerebral infarction than in those with lipid lowering and serum CRP levels.