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目的：探讨慢性肝炎病人中ＨＢＶ、ＨＣＶ、ＨＤＶ和ＨＧＶ四型肝炎病毒的感染和重叠感染对慢性肝炎的病情及预后的影响。方法：选择慢性肝炎病人１３６例，应用ＰＣＲ方法检测ＨＢＶＤＮＡ、ＨＣＶＲＮＡ、ＨＤＶＲＮＡ和ＨＧＶＲＮＡ，用ＥＬＩＳＡ法检测ＨＢＶ、ＨＣＶ、ＨＤＶ和ＨＧＶ其他血清学标志物。结果：上述四型肝炎病毒的感染模式为：ＨＢＶ、ＨＢＶ＋ＨＣＶ、ＨＢＶ＋ＨＤＶ、ＨＢＶ＋ＨＧＶ、ＨＣＶ和ＨＢＶ＋ＨＣＶ＋ＨＧＶ。六种感染模式的阳性率分别为６３．２％、１３．２％、１．５％、１２．５％、２．９％和６．６２％。除了慢性轻度型外，其余各型肝炎中上述重叠感染模式阳性率均明显高于单纯ＨＢＶ感染组。而ｒ－ＧＴ、ＡＬＴ、ＡＳＴ、ＡＬＰ均高于ＨＢＶ组，Ｃｈｅ活性则明显低于ＨＢＶ组，未见ＨＧＶ单纯感染。结论：在ＨＢＶ感染基础上重叠感染ＨＣＶ、ＨＤＶ和ＨＧＶ可使慢性肝炎病情加重，向慢肝重度、慢重肝和肝硬化发展。广西少见单纯ＨＧＶ感染所致的慢性肝炎，说明ＨＧＶ致病作用较弱，而ＨＶＢ感染是广西慢性肝炎主要致病因素，ＨＣＶ少见，多为输血引起感染并易转为慢性肝炎
Objective: To investigate the effect of hepatitis C, HCV, HDV and HGV hepatitis B virus infection and overlapping infection on the condition and prognosis of chronic hepatitis in patients with chronic hepatitis. Methods: Thirty-six patients with chronic hepatitis were selected. HBVDNA, HCVRNA, HDVRNA and HGVRNA were detected by PCR, and other serological markers of HBV, HCV, HDV and HGV were detected by ELISA. Results: The infection patterns of the four hepatitis viruses were HBV, HBV + HCV, HBV + HDV, HBV + HGV, HCV and HBV + HCV + HGV. The positive rates of the six infection modes were 63.2%, 13.2%, 1.5%, 12.5%, 2.9% and 6.62%, respectively. In addition to chronic mild type, the other types of hepatitis in the positive rate of the above overlapping infection were significantly higher than the simple HBV infection group. The r-GT, ALT, AST, ALP were higher than the HBV group, Che activity was significantly lower than the HBV group, no simple HGV infection. Conclusions: Over-infection of HCV, HDV and HGV on the basis of HBV infection can exacerbate the chronic hepatitis and progress toward chronic severe hepatitis, chronic severe hepatitis and cirrhosis. Guangxi rare HGV infection caused by chronic hepatitis, indicating that HGV pathogenesis weaker, and HVB infection is the main cause of chronic hepatitis in Guangxi, HCV rare, mostly due to blood transfusion infection and easy to switch to chronic hepatitis