论文部分内容阅读
目的:探讨单纯米索前列醇终止早期妊娠失败的临床疗效。方法:选择早期妊娠失败的患者310例,随机分为两组,Ⅰ组为研究组,采用阴道后穹窿放置米索前列醇,Ⅱ组为对照组,采用人工负压吸引术。再将Ⅰ组随机分为3个亚组,即Ⅰa、Ⅰb、Ⅰc组,分别给予米索前列醇400μg、600μg、800μg3个不同剂量,比较分析完全流产率、药物不良反应发生率、流产并发症发生率、月经复潮情况。结果:①Ⅰ组3个亚组之间,在完全流产率、流产并发症发生率方面,Ⅰa组与Ⅰb、Ⅰc组比较差异有统计学意义(P<0.01,P<0.05),Ⅰb组与Ⅰc组比较,差异无统计学意义(P>0.05);在药物不良反应发生率方面,Ⅰa组与Ⅰc组比较差异有统计学意义(P<0.05),Ⅰb组与Ⅰc组比较差异无统计学意义(P>0.05),但Ⅰb组低于Ⅰc组;②Ⅰb组与Ⅱ组间完全流产率比较差异无统计学意义(P>0.05),在流产并发症发生率方面,Ⅰb组与Ⅱ组比较差异有统计学意义(P<0.05);③两组流产后第1次月经周期均延迟,第2、3次月经周期基本恢复正常,两组间比较差异无统计学意义(P>0.05)。结论:单纯米索前列醇终止早期妊娠失败是安全有效的方法,最佳剂量为600μg,阴道后穹窿给药不良反应小,值得临床推广,替代人工负压吸引流产术,可减少流产并发症。
Objective: To investigate the clinical efficacy of simple misoprostol to terminate early pregnancy failure. Methods: A total of 310 patients with early pregnancy failure were randomly divided into two groups. Group Ⅰ was treated with misoprostol by vaginal posterior fornix. Group Ⅱ was treated by artificial negative pressure. Group I was randomly divided into three subgroups, namely Ⅰa, Ⅰb, Ⅰc group, were given misoprostol 400μg, 600μg, 800μg three different doses, comparative analysis of complete abortion rate, the incidence of adverse drug reactions, miscarriage complications Incidence, menstrual resurgence situation. Results: ① There was a significant difference between group Ⅰa and group Ⅰb and group Ⅰc (P0.01, P0.05), between Ⅰb group and Ⅰc There was no significant difference between the two groups (P> 0.05). There was significant difference between group Ⅰa and group Ⅰc in incidence of adverse drug reactions (P <0.05), but there was no significant difference between group Ⅰb and group Ⅰc (P0.05), but Ⅰb group was lower than Ⅰc group; ②Ⅰb group and Ⅱ group was no significant difference in the rate of complete abortion (P> 0.05), in the incidence of miscarriage, Ⅰb group and Ⅱ group difference (P <0.05). ③ The first menstrual cycle of both groups were delayed after abortion, and the second and third menstrual cycles returned to normal. There was no significant difference between the two groups (P> 0.05). Conclusions: The failure of simple misoprostol to terminate early pregnancy is a safe and effective method. The best dosage is 600μg. The posterior vaginal fornix administration has small adverse reactions. It is worthy of clinical promotion. It can replace abortion to reduce the complications of abortion.