目的:研究环孢素A(cyclosporin,CsA)诱发的牙龈肥大与CsA浓度的关系。方法:通过CsA用药后32例药物性牙龈肥大患者和对照组同期应用CsA后无牙龈肥大患者34例的血液、唾液、牙龈组织内的CsA的测定的观察和分析。结果:疾病发生和严重程度部位与血液、唾液和牙龈组织内的CsA浓度等有关,且差异具有显著性。结论:CsA诱发药物性牙龈肥大的发生率高,疾病发生和严重程度与血液、唾液和牙龈组织内的CsA浓度关系密切。 Objective: To study the relationship between gingival hypertrophy induced by cyclosporin (CsA) and CsA concentration. Methods: The CsA in blood, saliva and gingival tissues of 34 patients without gingival hypertrophy after CsA administration were observed and analyzed in 32 patients with drug-induced gingival hypertrophy and control group after CsA administration. Results: The incidence and severity of disease were related to the concentration of CsA in blood, saliva and gingival tissues, and the difference was significant. CONCLUSIONS: The incidence of gingival hypertrophy induced by CsA is high, and the incidence and severity of the disease are closely related to the concentration of CsA in blood, saliva and gingival tissues.