硝苯吡啶广泛用于治疗心绞痛和高血压。某些关于本药对糖代谢和胰岛素分泌作用的研究表明,它具有潜在的致糖尿病作用。作者报道2例患者,1例在服用硝苯吡啶期间糖尿病恶化,另1例发生糖尿病,停药后此作用消失。病例1为56岁男性患者,在1982年发现患糖尿病,自1969年患高血压和Ⅳ型高脂血症,1978年曾发生过1次心肌梗塞。患者的糖尿病由饮食控制,且服用心得安、氯噻酮、消心痛和安妥明等药。在1983年 Nifedipine is widely used in the treatment of angina and hypertension. Some of the drug on glucose metabolism and insulin secretion studies have shown that it has a potential role in diabetes. The authors reported 2 patients, 1 in the course of taking nifedipine during the deterioration of diabetes, another case of diabetes, after stopping this effect disappears. Case 1 was a 56-year-old male patient with diabetes mellitus in 1982, high blood pressure and type IV hyperlipidemia since 1969 and 1 myocardial infarction in 1978. Diabetes patients diet control, and taking propranolol, chlorthalidone, heartburn and clofiban and other drugs. In 1983