抗生素的广泛应用使人们注意到它对机体防御功能的影响。观察氯霉素和链霉素对大鼠肺巨噬细胞的多种功能改变,结果显示两种抗生素均可使大鼠肺巨噬细胞吞噬中性红能力下降,酵母多糖刺激后鲁米诺依赖的细胞化学发光强度降低,肺巨噬细胞内酸性磷酸酶活性减弱和异质荧光染色后一种代表免疫功能活跃的鲜蓝色荧光细胞亚群数量减少。由此表明氯霉素和链霉素能干扰大鼠肺巨噬细肿的正常功能。 The widespread use of antibiotics draws attention to its impact on the defense function of the body. Observed chloramphenicol and streptomycin on rat lung macrophage function changes, the results show that both antibiotics can make rat macrophages phagocytose neutral red decreased ability of lipopolysaccharide stimulated luminol dependence Decreased the chemiluminescence intensity of the cells, decreased the activity of acid phosphatase in the lung macrophages and decreased the number of bright blue fluorescent cell subpopulations that represent the immunologically active cells after heterogeneous fluorescence staining. This shows that chloramphenicol and streptomycin can interfere with the normal function of rat pulmonary macrophages.