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连续数天日间最大呼气流量(PEFR)改变可反映哮喘的严重程度,测定1分钟用力呼气量(FEV_1)也是估价哮喘严重程度的简便方法。本文研究控制良好的哮喘病儿,停药后6天内几项肺功能指标昼夜间的变化情况,以及这些指标的变化和控制疾病所需的药物是否可用于预测哮喘病儿停用维持治疗后昼夜间的病情变化的幅度。研究的第二个目的,是去探讨肺部症状或PEFR降低是否是疾病恶化的首发征象。方法哮喘病儿40例,女11例,男29例,年龄8～15岁(10.9±1.9),均有哮喘发作史,经色甘酸钠,吸入皮类固醇和支气管扩张剂控制了症状,根据临床表现及客观检查,如组织胺吸入诱发试验和常见过敏原的皮肤试验,进行维持治疗。所有病例研究前3个月内的组织胺阈值均<32mg/ml,至少有一项屋内尘螨浸出物皮内过敏试验阳性。研究前6个月内未服用皮质类固醇。于研究开始的第1天晨测定PEFR和
Changes in maximum daily expiratory flow (PEFR) over several consecutive days reflect the severity of asthma. Measuring 1-minute forced expiratory volume (FEV_1) is also a convenient method of assessing the severity of asthma. In this paper, the study of controlled children with asthma, six days after withdrawal of lung function changes in the number of day and night, and changes in these indicators and the control of the drug required for the disease can be used to predict the prognosis of asthmatic children after maintenance treatment day and night The extent of the change between the conditions. The second purpose of the study was to investigate whether lung symptoms or reduced PEFR are the first signs of disease progression. Methods A total of 40 asthmatic children, 11 females, 29 males, aged from 8 to 15 years (10.9 ± 1.9 years) had asthma attacks. The symptoms were controlled by cromolyn, inhaled corticosteroids and bronchodilators. According to the clinical Performance and objective examination, such as histamine inhalation induction test and common allergen skin test, maintenance treatment. Histamine thresholds were <32 mg / ml within the first 3 months of all case studies and at least one intradermal dust mite extract had an intradermal allergy test positive. Corticosteroids were not taken within the first 6 months of the study. PEFR was measured on the first day of the study