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目的:优选补脾益肠丸中挥发油的提取和β-环糊精包合工艺。方法:以挥发油提取量为指标,采用正交试验优选挥发油提取工艺;以挥发油包合率和包合物收得率为指标,采用正交试验优选挥发油包合工艺。结果:挥发油提取最佳工艺条件为:药材浸泡1 h,加6倍量水,提取6 h。挥发油包合最佳工艺条件为:β-环糊精与挥发油用量比例为6∶1,包合温度30℃,包合时间3 h。结论:所优选的挥发油提取工艺收油率高,包合工艺稳定、可靠。
Objective: To optimize the extraction of volatile oil in Bupisanyichang pill and β-cyclodextrin inclusion process. Methods: Taking the amount of volatile oil as an index, the orthogonal test was used to optimize the extraction process of volatile oil. The inclusion rate of volatile oil and the yield of inclusion compound were used as indexes. Orthogonal test was used to optimize the inclusion process of volatile oil. Results: The optimum extraction conditions for volatile oil were as follows: the medicinal materials were soaked for 1 h, 6 times the amount of water and extracted for 6 h. The optimum conditions for inclusion of volatile oil were as follows: the ratio of β-cyclodextrin to volatile oil was 6:1, the inclusion temperature was 30 ℃ and the inclusion time was 3 h. Conclusion: The best extraction rate of volatile oil extraction process is high, the inclusion process is stable and reliable.