【摘 要】
：
A new method for the preparation of 9-β-D-2’-deoxyribofuranosyl-6-methylpurine from inosine (1) is described.Inosine was converted to 6-chloropurinenucleoside
【机 构】
：
Institute of Radiation and Irradiation Medicine,Academy of Military Medical Science,Beijing 100850,C
论文部分内容阅读
A new method for the preparation of 9-β-D-2’-deoxyribofuranosyl-6-methylpurine from inosine (1) is described.Inosine was converted to 6-chloropurinenucleoside (4) via acetylation,chlorination,and deacetylation.Compound 4 was transformed to the key intermediate 6-methylpurinenucleoside (7) via protection of the 2’,3’,5’-hydroxy groups of 4 with 3,4-dihydropyran to give compound 5,then methylation at the 6-position of 5 with dimethyl copper lithium gave compound 6; depyranylation of 6 led to the subsequent selective protection of the 3’,5’-hydroxy groups of 7 with O[Si(I-Pr)2C1]2 followed by reaction with phenyl chlorothionoformate to give compound 9.Compound 9 was then converted to the target compound 11 via 2’-deoxidation and 3’,5’-desilylation.The structures of these products were identified by Mass Spectrum (MS),1H-NMR (Nuclear Magnetic Resonance) spectra and elemental analysis.
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