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Barrett食管是指食管下段的复层鳞状上皮被单层柱状上皮替代的一种病理现象早年曾一度认为其本质为先天性胃粘膜异位(heterotopia)。1950年,Barrett经观察先天性短食管及消化性食管溃疡的病变后首先指出,该病理现象与长期胃内容物返流有关,常为返流性食管炎后期的形态学表现。此后,文献中遂以Barrett食管(BE)命名并沿用至今。近年来,随着纤维内窥镜活检的广泛开展,以及粘液组织化学、生化酶学、超微结构研究的深入,对BE本质的认识渐趋完善,认为属于食管粘膜的胃化生或肠化生性变化。晚近,由于发现BE与食管腺癌的发生有密切关系而更受重视,被认为是食管腺癌的一种癌前病变
Barrett’s esophagus is a pathological phenomenon in which the lower esophageal squamous epithelium is replaced by a single layer of columnar epithelium, which was once thought to be inherently heterotopia of congenital gastric mucosa. After observing the lesions of congenital short esophageal and digestive esophageal ulcer in 1950, Barrett first pointed out that this pathological phenomenon is related to the reflux of long-term gastric contents and is often the morphological manifestation of retrograde esophagitis. Since then, the literature was named after the Barrett’s esophagus (BE) and has been in use so far. In recent years, with the extensive development of biopsy of fiber endoscopy, as well as mucus histochemistry, biochemical enzymes, ultrastructural studies, understanding of the nature of the BE gradually improved, that is, gastric metaplasia or intestinal metaplasia Changes in nature. Recently, BE and esophageal adenocarcinoma found more closely due to the occurrence of esophageal cancer is more attention, is considered a precancerous lesion of esophageal adenocarcinoma