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本实验用了610只大鼠、少量豚鼠、家兔和狗,研究了 Tiron 这种螯合剂对接受致死剂量硝酸铀酰中毒动物的排铀治疗效果。实验结果表明,Tiron 在促排核素和降低死亡率上明显地优于EDTA 和 DTPA。在对照组中,90—100%的动物在30天内因铀中毒而死亡;但用 Tiron 治疗的动物中,90—100%的动物都能在实验期内活存下来。给与 Tiron 的动物,其尿铀排出量比对照组多1—2倍。但若在注射核素后24小时给与 Tiron 时,不如早期给药那么有效。Tiron 对肾的毒性比 EDTA 和 DTPA 都低,对小鼠和大鼠的 LD_(SO)为6克每公斤体重左右。
In this experiment, 610 rats, a small amount of guinea pigs, rabbits and dogs were used to study the effect of Tiron chelator on uranium-depleted uranium poisoning in lethal doses of uranyl nitrate poisoning animals. The experimental results show that Tiron is significantly superior to EDTA and DTPA in promoting radionuclide and reducing mortality. In the control group, 90-100% of animals died of uranium poisoning within 30 days; however, 90-100% of animals treated with Tiron survived the experiment. Animals given Tiron had 1-2 times more urinary uranium excretion than controls. However, given Tiron 24 hours after injection of nuclide, it is less effective than early administration. Tiron is less toxic to the kidneys than EDTA and DTPA and has an LD_ (SO) of 6 grams per kilogram of body weight for mice and rats.