受体学说的建立和中枢神经递质的发现,不仅有助于解释精神安定剂(neuroleptics)的作用机理,而且为筛选新的、更有效的精神安定剂提供了理论和实验依据。本文对中枢多巴胺(DA)受体的某些概念及与精神药理学的关系,作一梗概介绍。 一、DA受体的分类 传统认为DA能神经末梢释放的DA作用于突触后膜DA受体,然后激活突触后神经元内的腺苷酸 The establishment of receptor theory and the discovery of CNS neurotransmitters not only help to explain the mechanism of action of neuroleptics, but also provide theoretical and experimental evidence for screening new and more effective neuroleptics. In this paper, some concepts of central dopamine (DA) receptors and their relationship with psychopharmacology are summarized. First, the classification of DA receptors Traditionally considered DA DA nerve endings release of DA on the postsynaptic membrane DA receptor, and then activate the postsynaptic neuron adenosine