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目的研究替米沙坦对2型糖尿病合并高血压的患者血压以及代谢指标的控制效果。方法选择60例2型糖尿病合并高血压患者,给予替米沙坦80mg,1次/d口服,同时治疗糖尿病及其他并发症。结果治疗3个月后,血压、血浆胰岛素水平、血糖、HbA1c、血脂变化差异有统计学意义(P<0.05)。结论替米沙坦可明显改善2型糖尿病的代谢障碍,可能通过激活过氧化物酶体增殖物激活受体(γ(PPAR(γ)等多途径实现降压及降血糖的效果,适合于代谢综合征的治疗。
Objective To study the effect of telmisartan on blood pressure and metabolic parameters in type 2 diabetic patients with hypertension. Methods Sixty patients with type 2 diabetes mellitus and hypertension were treated with telmisartan 80 mg orally once daily for the treatment of diabetes mellitus and other complications. Results After 3 months of treatment, the changes of blood pressure, plasma insulin level, blood glucose, HbA1c and blood lipid were statistically significant (P <0.05). Conclusion Telmisartan can ameliorate the metabolic disturbance of type 2 diabetes mellitus, and may be effective in lowering blood pressure and lowering blood glucose by activating multiple pathways of peroxisome proliferator-activated receptor (γ (PPAR (γ)), which is suitable for metabolism Syndrome treatment.