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目的分析和综述实验性缺血缺氧与学习记忆功能的关系,以期对航空医学工作者研究+Gz暴露问题有所启示。资料来源与选择该领域的研究论文、综述、研究报告和专著。资料引用论文、综述和研究报告28篇,专著1本。资料综合综述缺血缺氧暴露后学习记忆功能的变化情况,分析其病理变化特点及可能的机制。并回顾了实验条件下+Gz暴露后动物的学习记忆功能变化的相关研究。结论在实验性脑缺血或持续高+Gz暴露时,可以发现伴随相关脑区及相关基因表达的病理性改变,动物出现学习记忆功能的损害。与动物实验比,由于军事飞行员所受的+Gz值较小、持续时间较短,因此,需要进一步研究以揭示持续高+Gz暴露与战斗机飞行员学习记忆功能的关系。
Objective To analyze and summarize the relationship between experimental hypoxic-ischemic and learning and memory functions in order to provide some insights into aeromedical workers’ research on + Gz exposure. Sources and selection of research papers, reviews, research reports and monographs in this area. Information cited papers, reviews and research reports 28, a monograph. Materials A review of the changes of learning and memory function after hypoxia and hypoxia exposure was made, and the characteristics of the pathological changes and possible mechanisms were analyzed. The related research on animal learning and memory function after + Gz exposure was also reviewed. Conclusions During experimental cerebral ischemia or sustained high + Gz exposure, we found that learning and memory impairment occurred in animals accompanied by the pathological changes of related brain regions and related genes. Compared to animal experiments, military pilots suffer from shorter durations and shorter + Gz values, so further research is needed to reveal the relationship between sustained high + Gz exposure and learning and memory of fighter pilots.