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目的了解北京市海淀区新生儿脐带血麻疹抗体水平,为控制小月龄儿童麻疹发病提供科学依据。方法随机选取在北京市海淀区妇幼保健院分娩的产妇及其新生儿,采用酶联免疫吸附试验方法(ELISA)检测脐带血麻疹Ig G抗体。结果共采集1 027份脐带血标本,脐带血麻疹Ig G抗体阳性率为91.24%,达到保护性水平为54.63%,几何平均浓度(GMC)为897.113 m IU/ml。本市和外来户籍母亲新生儿脐带血麻疹抗体GMC分别为787.07 m IU/ml和967.88 m IU/ml,阳性率分别为87.76%和93.31%,不同户籍母亲之间抗体水平和阳性率差异有统计学意义。不同性别、胎龄和体重新生儿脐带血麻疹抗体GMC和阳性率差异无统计学意义。结论北京市海淀区新生儿麻疹抗体达到保护性水平较低,母亲为本市户籍的低于外地户籍,可以通过育龄期妇女接种麻疹疫苗来提高,以达到预防小月龄婴儿麻疹发病的目的。
Objective To understand the level of neonatal umbilical cord blood measles antibody in Haidian District of Beijing and provide a scientific basis for controlling the incidence of measles in children with Xiao month. Methods The mothers and their newborns delivered at Haidian Maternal and Child Health Hospital of Beijing were randomly selected. IgM antibodies against umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA). Results A total of 1 027 cord blood samples were collected. The positive rate of IgG antibodies against umbilical cord blood measles was 91.24%, reaching a protective level of 54.63%. The geometric mean concentration (GMC) was 897.113 m IU / ml. The neonatal umbilical cord blood measles antibody GMC was 787.07 m IU / ml and 967.88 m IU / ml respectively, the positive rates were 87.76% and 93.31%, respectively, and there were statistics on the difference of antibody level and positive rate between different mothers and their mothers Significance of learning. There was no significant difference in the GMC and the positive rate of umbilical cord blood measles antibody in different sex, gestational age and weight neonates. Conclusion The neonatal measles antibody in Haidian District of Beijing has a low protective level. The mothers whose registered permanent residence in the city is lower than their registered permanent residents can be vaccinated by women of childbearing age to improve the measles vaccine so as to prevent the onset of measles.