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目的观察莫沙必利联合奥美拉唑治疗反流性食管炎的疗效。方法将100例患者随机分为治疗组(50例)和对照组(50例)。治疗组:奥美拉唑20mg,每日1次,莫沙必利5mg,每日3次口服。对照组:奥美拉唑20mg,每日1次口服。治疗前及治疗后2、4、6周计算患者症状积分。治疗后6周复查胃镜,观察胃镜下愈合率,并进行24h食管pH监测。结果治疗组临床有效率为100%,内镜下有效率为96%;对照组分别为88%和84%,两组比较差异有显著性(P<0.05)。6周后两组pH<4反流总次数及反流总时间百分率均显著降低(P<0.05),且两组间差异有统计学意义(P<0.05)。结论莫沙必利联合奥美拉唑治疗反流性食管炎比单用奥美拉唑具有更好的疗效。
Objective To observe the efficacy of mosapride combined with omeprazole in the treatment of reflux esophagitis. Methods 100 patients were randomly divided into treatment group (50 cases) and control group (50 cases). Treatment group: omeprazole 20mg, 1 day, mosapride 5mg, 3 times a day orally. Control group: omeprazole 20mg, 1 day orally. Before treatment and 2, 4, 6 weeks after treatment, patients’ symptom scores were calculated. The gastroscope was reviewed 6 weeks after the treatment, the healing rate under the gastroscope was observed, and the esophageal pH was monitored for 24 hours. Results The clinical effective rate was 100% in the treatment group and 96% in the endoscopic treatment group. The control group was 88% and 84% respectively. There was significant difference between the two groups (P <0.05). After 6 weeks, the total number of reflux of pH <4 and the total time of reflux were significantly decreased (P <0.05), and there was significant difference between the two groups (P <0.05). Conclusion Mosapride combined with omeprazole in the treatment of reflux esophagitis is more effective than omeprazole alone.