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目的探讨测定超重/肥胖孕妇血清中纤维连接蛋白(FN)的水平来评价罹患先兆子痫的风险。方法选取132例血压正常的非先兆子痫孕妇(正常体重者80例,超重/肥胖者52例)和26例先兆子痫孕妇(正常体重者12例,超重/肥胖者14例),采用酶联免疫吸附法(ELISA)测检血清中的FN水平。结果未发生先兆子痫的孕妇中,超重/肥胖组与正常体重组相比,血清中FN与平均动脉压(MAP)均显著升高(P均<0.01),且超重/肥胖组孕妇血清中FN含量与MAP呈正相关(r=0.685,P<0.05)。而发生先兆子痫的孕妇,超重/肥胖组与正常体重组相比,血清中FN浓度无统计学差异(P>0.05);然而发生先兆子痫孕妇的血清中FN比正常孕妇显著增高(P<0.01),比正常孕妇中的超重/肥胖者也要明显升高(P<0.01)。结论血清中FN水平升高可能是先兆子痫的一种危险因素,特别是对于超重/肥胖的孕妇。
Objective To investigate the level of fibronectin (FN) in serum of overweight / obese pregnant women to evaluate the risk of preeclampsia. Methods 132 non-preeclamptic pregnant women (normal weight 80, overweight / obesity 52) and 26 pregnant women with preeclampsia (12 normal weight and 14 overweight / obese) Serum FN levels were measured by ELISA. Results In pregnant women without preeclampsia, the levels of FN and MAP in serum of overweight / obesity group were significantly higher than those of normal weight group (all P <0.01), and those of overweight / obesity group FN content was positively correlated with MAP (r = 0.685, P <0.05). However, there was no significant difference in serum FN concentrations between pregnant and overweight / obese patients with preeclampsia (P> 0.05). However, serum FN in pregnant women with preeclampsia was significantly higher than that in normal pregnant women (P <0.01), which was significantly higher than that of overweight / obesity in normal pregnant women (P <0.01). Conclusions Elevated serum FN levels may be a risk factor for preeclampsia, especially for overweight / obese pregnant women.