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通过对30名慢性气道阻塞性疾病患者进行定量吸入器(MDI)与定量吸入器连接贮雾助吸器(spacer)吸入β2受体兴奋剂疗效的对照观察,证明MDI连接spacer吸入β2兴奋剂,可明显减少药雾在咽部的沉积,使肺内沉积率提高55.8%(Ρ<0.001),从而显著提高FEV1.0(P<0.05)、PEF(P<0.05)、V50(P<0.05)及V25(P<0.01)4项指标,减少用药量及心血管副作用。且不需特殊训练,不需吸气与手术动作配合及较长时间屏气。尤适用于老人、肺功能差及气急明显者。
By comparing the efficacy of MDI inhalation with inhalation of β2 receptor agonists by a metered-dose inhaler and spacer spacer in 30 patients with chronic airway obstructive disease, it was demonstrated that MDI connection spacer inhaled β2 agonist, (P <0.05), PEF (P <0.05), PEF (P <0.05), and the deposition rate in the lung increased 55.8% (P <0.001) ), V50 (P <0.05) and V25 (P <0.01), and the dosage and cardiovascular side effects were decreased. And without special training, without breathing and surgical action with a longer time breath holding. Especially suitable for the elderly, poor lung function and those who have shortness of breath obviously.