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目的探讨阿托伐他汀钙预防动脉粥样硬化形成的临床作用。方法入选2010年9月～2011年9月在某院进行健康查体人群84例,给予阿托伐他汀钙10mg/d,观察两年,干预前后测量所有受试者颈动脉内膜中层厚度(IMT)、踝臂指数(ABI)、脉搏波传导速度(PWV),比较各指标干预前后的变化。结果干预结束后,受试者动脉硬化程度显著改善,IMT、ABI、PWV较干预前差异均有统计学意义(P﹤0.05);收缩压、总胆固醇、低密度脂蛋白胆固醇均显著降低,差异有统计学意义(P﹤0.05)。结论阿托伐他汀钙能稳定血管内斑块,增加血管弹性,延缓粥样硬化的发展,且不良反应少,安全性好。
Objective To investigate the clinical effect of atorvastatin on the prevention of atherosclerosis. Methods Eighty-four healthy volunteers in a hospital from September 2010 to September 2011 were enrolled in this study. Atorvastatin calcium 10 mg / d was given for two years. Before and after the intervention, the carotid intima-media thickness IMT), ankle brachial index (ABI) and pulse wave velocity (PWV). The changes of each index before and after intervention were compared. Results At the end of intervention, the severity of atherosclerosis was significantly improved, and the differences of IMT, ABI and PWV were statistically significant (P <0.05); the systolic blood pressure, total cholesterol and low density lipoprotein cholesterol were significantly decreased There was statistical significance (P <0.05). Conclusions Atorvastatin calcium can stabilize the intravascular plaque, increase the elasticity of blood vessel and delay the development of atherosclerosis, with less adverse reactions and good safety.