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我们曾报告(1982)将强啡肽A5-40μg注入大鼠脊髓蛛网膜下腔产生强烈的镇痛作用。本工作将强啡肽A(1-13)酰胺0.2或0.4mg给三名主诉剧痛的晚期直肠癌患者作脊髓蛛网膜下腔注射,二例产生明显的镇痛作用,疼痛减轻50—80％,一例无效。三例五次注射未见任何运动障碍或呼吸抑制现象。
We have reported (1982) that a strong analgesic effect of dynorphin A5-40 μg injected into the spinal cord subarachnoid space of rats. In this work, 0.2 or 0.4 mg of dynorphin A (1-13) amide was given to three patients with advanced colorectal cancer who complained of acute pain in the spinal cord for subarachnoid injection. Two cases had obvious analgesic effect and the pain was reduced by 50-80 %, An invalid case. Three cases of five injections showed no signs of dyskinesia or respiratory depression.