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本工作以钾离子透入法引起大鼠甩尾反应的电流强度(mA)为痛反应指标,观察了侧脑室注射催产素(OT)及抗催产素血清(AOTS)对大鼠痛阈和电针镇痛效应的影响。注射50 ngOT 后80min 内,大鼠痛阈比注药前增加20—38%。与注射生理盐水组的痛阈相比有非常明显的增高(p<0.01—0.001),侧脑室注射 OT 后电针期内,痛阈增加139—234%,与生理盐水电针组相比,有显著差异(P<0.05—0.01)。OT 的剂量在25—100ng 范围内,其增强电针镇痛效应有明显的剂量-效应关系。注射 AOTS 后,电针镇痛应明显低于注射正常兔血清(NRS)组(p<0.05—0.01)。上述结果表明,侧脑室注射 OT,既可提高痛阈又可明显地增强电针镇痛效应,而用 AOTS消除内源性 OT 的作用后,电针镇痛效应明显降低。这提示,中枢神经系统内的 OT 在电针镇痛过程中,发挥一定的作用
In this work, the current intensity (mA) of rat tail flick reaction induced by potassium ion penetration method was taken as the index of pain reaction. The effects of intracerebroventricular injection of oxytocin (OT) and anti-oxytocin serum (AOTS) Effects of Needle Analgesia. After injection of 50 ngOT for 80 minutes, the pain threshold in rats increased by 20-38% compared with that before injection. Compared with saline injection group, the pain threshold was significantly increased (p <0.01-0.001). After intracerebroventricular injection of OT, the pain threshold increased by 139-234% during electroacupuncture. Compared with saline electroacupuncture group, There was a significant difference (P <0.05-0.01). The dose of OT is in the range of 25-100ng, which has obvious dose-effect relationship to enhance the electroacupuncture analgesic effect. After AOTS injection, the analgesia of electroacupuncture should be significantly lower than that of normal rabbits injected with serum (NRS) (p <0.05-0.01). The above results show that intracerebroventricular injection of OT can not only improve the pain threshold but also significantly enhance the analgesic effect of electroacupuncture. However, the effect of electro-acupuncture analgesia is obviously reduced after the endogenous OT is eliminated with AOTS. This suggests that OT in the central nervous system plays a role in the electroacupuncture analgesia