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目的：探讨蝮蛇抗栓酶治疗糖尿病肾脏病变的疗效。方法：测定17例糖尿病人用蝮蛇抗栓酶治疗前及治疗半月后的24小时尿蛋白量、肌酐和尿素氮并进行分析。结果：治疗前尿蛋白平均值为1．98±2．059／24h，治疗后平均值为0．89±0．95g／24h，有显著性下降（P＜0．05）；治疗前肌酐平均值为112．93±15．85mmol／L，治疗后平均值为98．23±8．41mmol／L，亦有显著性下降（P＜0．05）；尿素氮治疗前（平均值为6．05±2．76mmol／L）与治疗后（平均值为7．01±4．08mmol／L）差异不显著（P＞0．05）。结论：蝮蛇抗栓酶治疗糖尿病临床肾脏病变有明显减少尿蛋白量和降低肌酐值的作用。
Objective: To investigate the curative effect of Agkistrodon antithrombin on diabetic nephropathy. Methods: The proteinuria, creatinine and urea nitrogen of 17 diabetic patients before and after half a month of treatment were measured. Results: The average value of urine protein before treatment was 1.98 ± 2.059 / 24h and the average value after treatment was 0.89 ± 0.95g / 24h (P <0.05). Before treatment, creatinine average (112.93 ± 15.85mmol / L), and the average value after treatment was 98.23 ± 8.41mmol / L, also decreased significantly (P <0.05). 05 ± 2.76mmol / L) and after treatment (average 7.01 ± 4.08mmol / L), the difference was not significant (P> 0.05). Conclusion: The treatment of diabetic nephropathy with viper antithrombin has a significant effect on reducing urinary protein and creatinine.