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目的观察川芎嗪联合奥扎格雷治疗急性脑梗死对患者血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)及白细胞介素-6(IL-6)水平的影响。方法选取急性脑梗死患者120例,所有患者均根据病情给予脱水药,控制血压、血糖、血脂药物,预防应激性溃疡及防止电解质紊乱、酸碱失衡、感染及压疮等并发症。治疗后观察治疗效果,比较治疗前后的神经功能缺损评分及血清hs-CRP、MMP-9及IL-6水平。结果 120例患者治疗总有效率为95.8%;治疗后的神经功能缺损评分低于治疗前,治疗后的血清hs-CRP、MMP-9及IL-6水平均低于治疗前,差异均有统计学意义(P<0.05)。结论川芎嗪联合奥扎格雷治疗急性脑梗死疗效较好,可显著降低急性脑梗死患者血清hs-CRP、MMP-9及IL-6水平,减轻炎性反应,改善神经功能缺损,改善患者的预后。
Objective To investigate the effects of ligustrazine plus ozagrel on serum hs-CRP, MMP-9 and IL-6 in patients with acute cerebral infarction . Methods A total of 120 patients with acute cerebral infarction were selected. All patients were given dehydration medicine to control blood pressure, blood sugar, lipids, prevent stress ulcer and prevent electrolyte imbalance, acid-base imbalance, infection and pressure sore. After treatment, the therapeutic effect was observed. The neurological deficit scores, serum hs-CRP, MMP-9 and IL-6 levels before and after treatment were compared. Results The total effective rate was 95.8% in 120 patients. The score of neurological deficit after treatment was lower than before treatment, and the levels of serum hs-CRP, MMP-9 and IL-6 after treatment were lower than those before treatment Significance (P <0.05). Conclusion Ligustrazine combined with ozagrel treatment of acute cerebral infarction better curative effect, can significantly reduce the serum levels of hs-CRP, MMP-9 and IL-6 in patients with acute cerebral infarction, reduce inflammatory response, improve neurological deficits and improve the prognosis of patients .