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目的 评价平阳霉素碘油乳剂 (PLE)局部给药治疗 5cm以上肝海绵状血管瘤 (CHL)的临床疗效及安全性。方法 对 15 6例CHL行PLE局部治疗 ,其途径包括 :经肝动脉 15 4例 ,经门静脉 1例、经皮直接瘤内注射 1例。分别观察其治疗前后肿瘤大小变化、临床症状的缓解和并发症的情况。结果 经肝动脉 15 4例 ,除 2例治疗后仍手术切除者外 ,其余 15 2例栓塞前肿瘤直径 (8 7±2 4 )cm ,栓塞后 3个月为 (4 8± 1 8)cm(P <0 0 1) ,栓塞后 6个月为 (1 9± 1 6 )cm(P <0 0 1)。经门静脉和直接穿刺各 1例治疗后瘤体均缩小。临床症状大部缓解。结论 CHL的局部PLE硬化治疗是疗效良好且安全的方法。
Objective To evaluate the clinical efficacy and safety of local administration of Pingyangmycin lipiodol emulsion (PLE) in the treatment of hepatic cavernous hemangiomas (CHL) of more than 5 cm. Methods 15 cases of CHL underwent PLE local treatment, including: via the hepatic artery in 15 4 cases, 1 case of portal vein, 1 case of direct intratumoral injection. Respectively observed before and after treatment of tumor size changes, clinical symptoms and complications. Results There were 15 4 cases of hepatic artery, except for 2 cases who were still undergone surgical resection. The other 152 cases had an embolization diameter of (87 ± 2 4) cm and a mean of (48 ± 1 8) cm 3 months after embolization (P <0.01), and 6 months after embolization was (19 ± 16) cm (P <0.01). After the portal vein and direct puncture in 1 case of the treatment of tumors were reduced. Most clinical symptoms relieved. Conclusion CHL local PLE sclerotherapy is a good and safe method.