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3—[4—2(羟基乙基)哌嗪基]甲基—联苯对二酚(N_(22))为苯酚的衍生物,属非甾体类抗炎药。本文研究了N_(22)对体外培养心肌细胞的作用,结果表明N_(22)对大鼠体外培养心肌细胞搏动有明显的负性频率作用,并伴有搏动强度减弱作用;对自发性或由乌豆碱诱发的速发型心律失常有明显的对抗作用。
3- [4-2 (Hydroxyethyl) piperazinyl] methyl-biphenyl diphenol (N_ (22)) is a derivative of phenol, which belongs to non-steroidal anti-inflammatory drugs. In this paper, the effect of N_ (22) on cultured cardiomyocytes in vitro was studied. The results showed that N_ (22) had a significant negative frequency effect on cardiomyocytes pulsation in vitro, accompanied by a weakening of pulsating strength. Phyto-induced tachycardia arrhythmia obvious antagonism.