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脱镁叶绿酸-a甲酯与邻苯二胺发生缩合和重排反应,分别给出(2,3-n)-苯并咪唑并红紫素-18甲酯、(2,3-o)-苯并咪唑并红紫素-18甲酯、(2,3-n)-喹喔啉并焦脱镁叶绿酸甲酯和二氢卟吩-p6三甲酯.针对苯并咪唑并红紫素-18的20-meso-位和12-位甲基进行氟代、氯代、溴代、碘代和空气氧化反应,完成了一系列具有叶绿素基本碳架的苯并咪唑并二氢卟吩类衍生物的合成.所得新的叶绿素衍生物的化学结构均经UV,IR,1H NMR,质谱及元素分析予以证实.
Methyl pheophorbide-a condenses and rearranges with o-phenylenediamine to give (2,3-n) -benzimidazo-scandium-18 methyl ester, ) -benzimidazorhodrazin-18 methyl ester, (2,3-n) -quinoxaline and methyl pyropheophorbide and chlorin-p6 trimethyl ester. For the benzimidazo Fluoro, chloro, bromo, iodo and air oxidation reactions at the 20-meso- and 12-methyl groups of purpurogen-18 resulted in the completion of a series of benzimidazomo dihydrogen chlorides with basic chlorophyll carbons Synthesis of porphyrin derivatives The chemical structures of the new chlorophyll derivatives were confirmed by UV, IR, 1H NMR, MS and elemental analysis.