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目的 探讨转移相关基因CD4 4v6的表达与葡萄胎恶变的关系。方法 采用SP免疫组织化学法检测 1 997～ 2 0 0 1年 93例妊娠滋养细胞疾病 (gestationaltrophoblasticdiseases ,GTD)石蜡标本中CD4 4v6表达情况。结果 93例滋养细胞疾病标本中 ,CD4 4v6表达在葡萄胎组织中的表达显著低于滋养细胞肿瘤 (P <0 0 1 ) ;71例葡萄胎组织中恶变组CD4 4v6表达阳性率显著高于未恶变组 (P <0 0 5 ) ;滋养细胞由轻度至重度增生过程中 ,CD4 4v6表达阳性率逐渐增高。中重度组的CD4 4v6表达阳性率显著高于轻度增生组 (P <0 0 1 )。结论 在不同类型GTD中CD4 4v6表达率不同 ,恶变组葡萄胎组织的CD4 4v6表达明显高于未恶变的葡萄胎组织。葡萄胎组织中CD4 4v6过度表达者恶性程度相对增高
Objective To investigate the relationship between the expression of CD4 4v6 and the malignant transformation of hydatidiform mole. Methods SP immunohistochemistry was used to detect the expression of CD4 4v6 in 93 cases of gestational trophoblastic diseases (GTD) from 1997 to 2001. Results In 93 cases of trophoblastic disease, the expression of CD4 4v6 in hydatidiform mole was significantly lower than that in trophoblastic tumor (P <0.01). The positive rate of CD4 4v6 in malignant group was significantly higher than that in 71 cases Malignant group (P <0 05); trophoblast mild to severe hyperplasia, the positive rate of CD4 4v6 gradually increased. The positive rate of CD4 4v6 in moderate and severe group was significantly higher than that in mild hyperplasia group (P <0.01). Conclusion The expression of CD4 4v6 in different types of GTD is different. The expression of CD4 4v6 in malignant group is obviously higher than that of nonmalignant hydatidiform mole. Mole tissue CD4 4v6 overexpression of malignant degree is relatively high