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目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)白质变化与认知功能改变的关系,为OSAS认知功能损害的预防和治疗提供依据。方法选择OSAS患者63例,依据睡眠呼吸暂停低通气指数分成轻度、中度、重度3组,同时选取20例非OSAS作为对照组,均进行头颅MRI检查,观察脑白质的头颅MRI表现,并进行MMSE评分。结果 63例OSAS患者,头颅MRI显示44例脑白质改变,轻度组8例(50.00%)、中度组13例(68.42%)、重度组23例(82.14%),与对照组(2例)差异有统计学意义(χ2=11.59,P<0.05);MMSE评分4组差异有统计学意义(F=3.055,P<0.05)。结论 OSAS可以影响脑白质改变的发生发展,并且可能与患者的认知功能相关。因此干预OSAS可能减轻脑白质改变,进而减少认知功能障碍的发生。
Objective To investigate the relationship between changes of white matter and cognitive function in obstructive sleep apnea syndrome (OSAS), and to provide evidence for the prevention and treatment of OSAS cognitive impairment. Methods Sixty-three OSAS patients were divided into mild, moderate and severe OSA group according to sleep apnea-hypopnea index, and 20 non-OSAS patients were selected as control group. All patients underwent cranial MRI examination to observe the brain MRI manifestations of white matter MMSE score. Results In 63 OSAS patients, cranial MRI showed 44 cases of white matter changes, 8 cases (50.00%) in mild group, 13 cases (68.42%) in moderate group and 23 cases (82.14%) in severe group ) Had statistical significance (χ2 = 11.59, P <0.05). There was significant difference between MMSE score 4 groups (F = 3.055, P <0.05). Conclusion OSAS can affect the occurrence and development of white matter changes, and may be related to the patient’s cognitive function. Therefore, intervention with OSAS may reduce the white matter changes, thereby reducing the occurrence of cognitive dysfunction.